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USP Labs OxyElite Pro

1 Capsule

90

 
Amount
Per Serving
% Daily
Value
*
Proprietary Blend
119.5 mg
**
Bauhinia Purpurea L. (Leaf And Pod) Extract, Bacopa (Leaf) (Bacopa Monnieri) Extract, 1,3-Dimethylamylamine HCL, Cirsium Oligophyllum (Plant) Extract, Yohimbe (Pausinystalia Johimbe) Bark Extract
Caffeine
100 mg
**

* (DV) Daily Value based on a 2,000 calorie diet

** Percent Daily Values not established.

Other Ingredients:

Modified Starch, Gelatin, Magnesium Stearate, Silicon Dioxide, Red #3, Blue #1, Red #40, Titanium Dioxide.

Directions:

As a dietary supplement, take 1-2 capsules on an empty stomach before breakfast.  Take an additional 1 capsule six to eight hours later on an empty stomach, if needed.  Due to extreme potency, begin by taking 1 capsule before breakfast and 1 capsule six to eight hours later to assess tolerance.  DO NOT USE PRODUCT FOR LONGER THAN 8 WEEKS FOLLOWED BY A SUBSEQUENT 4 WEEK BREAK.  DO NOT EXCEED 3 CAPSULES IN ANY 24 HOUR PERIOD.

Warnings:

This product is only intended to be consumed by healthy adults 18 years of age or older.  Pregnant or nursing women should not use this product.  Consult with your health care provider before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement product or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAO-B inhibitor or any other medication, including but not limited to MAOIs, SSRIs, or any other compounds with serotonergic activity.  This product contains caffeine and should not be taken by individuals wishing to eliminate this ingredient from their diet.  Discontinue use 2 weeks prior to surgery.  Do not use in combination with other caffeinated products.  Discontinue use and immediately consult your health care professional if you experience any adverse reaction to this product.  Do not exceed recommended serving.  Do not use if safety seal is broken or missing.  This product may contain ingredients banned by certain sports organizations.  User assumes all risks, liabilities, or consequences respecting testing.  KEEP OUT OF REACH OF CHILDREN.

OxyElite Pro (Original Formula)

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  • OxyElite Pro (Original Formula)

Additional Information

Size No
Infomation

USP Labs OxyElite Pro

1 Capsule

90

 
Amount
Per Serving
% Daily
Value
*
Proprietary Blend
119.5 mg
**
Bauhinia Purpurea L. (Leaf And Pod) Extract, Bacopa (Leaf) (Bacopa Monnieri) Extract, 1,3-Dimethylamylamine HCL, Cirsium Oligophyllum (Plant) Extract, Yohimbe (Pausinystalia Johimbe) Bark Extract
Caffeine
100 mg
**

* (DV) Daily Value based on a 2,000 calorie diet

** Percent Daily Values not established.

Other Ingredients:

Modified Starch, Gelatin, Magnesium Stearate, Silicon Dioxide, Red #3, Blue #1, Red #40, Titanium Dioxide.

Directions:

As a dietary supplement, take 1-2 capsules on an empty stomach before breakfast.  Take an additional 1 capsule six to eight hours later on an empty stomach, if needed.  Due to extreme potency, begin by taking 1 capsule before breakfast and 1 capsule six to eight hours later to assess tolerance.  DO NOT USE PRODUCT FOR LONGER THAN 8 WEEKS FOLLOWED BY A SUBSEQUENT 4 WEEK BREAK.  DO NOT EXCEED 3 CAPSULES IN ANY 24 HOUR PERIOD.

Warnings:

This product is only intended to be consumed by healthy adults 18 years of age or older.  Pregnant or nursing women should not use this product.  Consult with your health care provider before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement product or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAO-B inhibitor or any other medication, including but not limited to MAOIs, SSRIs, or any other compounds with serotonergic activity.  This product contains caffeine and should not be taken by individuals wishing to eliminate this ingredient from their diet.  Discontinue use 2 weeks prior to surgery.  Do not use in combination with other caffeinated products.  Discontinue use and immediately consult your health care professional if you experience any adverse reaction to this product.  Do not exceed recommended serving.  Do not use if safety seal is broken or missing.  This product may contain ingredients banned by certain sports organizations.  User assumes all risks, liabilities, or consequences respecting testing.  KEEP OUT OF REACH OF CHILDREN.

Deal Of the Day No

USP Labs OxyElite Pro - "It's like Jack3d in a pill with crazy fat burning!"

It has finally been unearthed, new OxyElite Pro (formerly known as USPLabs OEP), the revolutionary fat burning pill that eradicates even the most ferocious of appetites and increases energy output like no other. Oxy Elite Pro rips fat off like an adipose assassin without the harsh crash like other fat burners on the market.

What makes OxyElite Pro different from all the other fat burners out there? Simple, pharmacist-formulated ingredients at therapeutic levels to deliver fast results to get you shredded like never before!

A letter from the CEO of USPLabs

It Was Back in ‘92, But I Remember It Like Yesterday...

I walked into my local supplement shop and asked what I should take to get shredded...
Despite what seemed like hundreds of products, the guy said "ECA" as if there wasn't even a choice...

Those were the days...you simply popped a few of those bad boys and your appetite disappeared, fat melted away, energy skyrocketed & your body began to change...

The Same Old BS

Since then, stimulant-based "fat burners" have been all show and no go...

How many caffeine, green tea, synephrine and weak ass "thyroid-boosting" products can be released?

Who do they think they're kidding when the write-up says "We've produced the most unique & effective fat burner ever!"...

...Umm, no you haven't, it's the same as every other shitty burner on the market...

Can You Say HMB of the Fat Loss World?

Listen, green tea has MANY benefits...It's an awesome antioxidant and is rightfully a staple in many intelligent lifters arsenals...

And, yes, some science shows it boosts metabolism...but let's be honest, it's not gonna get you ripped...

My grandmother's been drinking it every day for decades and I'm pretty sure she doesn't have a six-pack...

And synephrine...don't even get me started with that crap...

...It wasn't effective when it was initially touted as "the next ephedra" ...and it's not effective now - despite it blindly being included in pretty much every formula out there...

After establishing Recreate as THE top-notch low-stim fat burner in existence, we set out to develop a stim-based fat burner that, well, actually burned fat!

...I'm proud to say we've hit paydirt...

Introducing a burner so laser-targeted, it's been coined the "Super Thermogenic™" by researchers familiar with its effectiveness...

It's called OxyELITE Pro™ and it's here to kick your ass & get you absolutely shredded...

Its potency is unmatched & its ability to deliver is flat-out staggering...

But don't believe me, check out what these lucky individuals who received a pre-release bottle had to say...

"The thermogenic effects were evident after about 10 minutes of dosing 1 capsule of OxyELITE Pro™ and continue, my whole body is sweating at the moment and it is about 68 in my place... Jacob, if I have to run my A/C in November!!!!" Matt Finnegan - Houston, TX

"I have lost 14 pounds from my weekly weigh in, and although it is unofficial I couldn't resist the scale today, says I had dropped another 5.5lbs ... OxyELITE Pro™ takes away your appetite, I mean demolishes it. The only time I am actually hungry is in the morning when I first wake up. A big difference for me. Huge difference." Benjamin Johnston - Tampa, FL

"Definitely feeling the heat on this stuff. I'm staying warm throughout the day - I love that feeling! The appetite suppression is killer too! Forcing myself to eat today... Within about 10 minutes, I felt OxyELITE Pro™ kick in. I've used the ECA stack a few times in the past. This was like a walk down memory lane! I felt the rush of energy. I felt the heat, and I felt the loss of appetite kick in. I looked over at my sandwich while driving & laughed out loud!! I felt great!!" Daniel Edney - Baton Rouge, LA

"As a pharmacist myself, I'd approve it. On ingredients alone, OxyELITE Pro™ will outperform everything on the market or anything planning to come to market. Nothing touches what is being used/how they are being used. Just awesome. You have really outdone yourself Jacob!" Anabolicminds.com member MrBigPR

"I have been on my diet for 3.5 weeks and lost 10 pounds. I have gotten stronger while on OxyELITE Pro™ during my cut - which absolutely blew my mind, never thought it would happen. I never ran out of energy even on the days I went extremely low calorie. I have to say that it really helped me maintain my muscle mass as well. I have never been able to diet like I just did and maintain as much mass and strength as I have while using OxyELITE Pro™. Guys and gals, this is truly the thermogenic that everyone has been waiting for. Fantastic fat loss and maintenance of muscle mass/strength. It certainly gets my recommendation and I'll never do a diet without it ever again." Sam Cox - Riley, Kansas

Why Is The Last Place To Lose Fat, The First Place To Gain Fat?

It just doesn't seem fair, but unfortunately it's true...

...It may be your stomach, your love handles or even your man boobs...

Fat sticks to these areas like super glue and hangs on for dear life...

So why does this happen?

Your BodyFat is Being Held Hostage

It's called the Alpha-2 receptor – And, if fat loss is your goal - it's your absolute worst enemy...

If the Alpha-2 receptor wants you to store fat, you're going to store fat – and lots of it – in the worst possible places ...

The alpha-2 receptor is responsible for inhibiting lipolysis - which basically means it allows the body to store fat AND prevents the body from burning fat...

In other words, the Alpha-2 receptor is holding your fat hostage & refusing to let go!

The Alpha-2 Receptor is abundant in certain areas of your body & non-existent in others...

As you can see in the illustration above, Alpha-2 receptors have been shown to be present in abdominals, lower chest, and buttocks – precisely where you don't want them to be!
This is exactly why your biceps are lean, yet your stomach is as smooth as a baby's ass...

The Alpha-2 Receptor is the technical term for "trouble spots"...

When it's activated, these areas are in "lock-down" - unable to burn fat and storing it like a bear preparing for hibernation...

Full-Fledged Thermogenesis

Luckily, this is where OxyELITE Pro™ shines...

By utilizing a compound shown to block off & deactivate the Alpha-2 receptor, we can use this to our advantage to torch fat quickly & efficiently – exactly where you want fat loss to occur!

Think of OxyELITE Pro™ as S.W.A.T – busting down doors and "freeing" your fat cells from their hostage situation...

So sit back & strap on your seatbelt as this very well may be the most important info you've ever read on fat loss...

The OxyELITE Pro™ lineup...


Rauwolfia Canescens (Rauwolscine)

This particular compound has been shown to block off & deactivate the Alpha-2 receptor!

It's related to yohimbine, a compound which is often included in various fat loss formulas because of its ability to antagonize alpha 2-adrenoceptors, allowing lipolysis itself, while also allowing lipolysis to continue from beta adrenoceptor agonism as well (11,12).

Here's the problem: While antagonizing alpha 2-adrenoceptors is great, yohimbine unfortunately also does the same for alpha 1-adrenoceptors – and this can actually hinder lipolysis (13).

So, on the other hand, while yohimbine helps to improve lipolysis by antagonizing alpha 2-adrenoceptors, it may also prevent lipolysis from occurring by antagonizing alpha 1-adrenoceptors...

Kind of defeats the purpose, huh? It's like robbing Peter to Pay Paul...

The end result is only a mediocre or small effect upon fat loss, or no detectable fat loss at all, which is what has been demonstrated in the literature with yohimbine supplementation (14-17).

Rauwolscine on the other hand, is just as potent at antagonizing alpha 2-adrenoceptors as yohimbine, yet it is 50 times less potent at alpha 1-adrenoceptors (18), making it much more selective and much less likely to reduce lipolysis by inhibiting alpha 1-adrenoceptor activity when compared to yohimbine.

Rauwolscine is clearly the better choice.

Last, beware of those products which contain the hydroxylated derivatives of yohimbine (e.g., 10-OH-yohimbine and 11-OH-yohimbine). They may look different but the truth is that they are no more effective than yohimbine (19).

This is simply a marketing gimmick designed to get the consumer to believe they are getting something truly unique and more effective.

Bauhinia purpurea L (Leaf & Pod [standardized for Bauhiniastatins 1-4])

This particular extract is very exciting because, due to various factors (e.g., stress, dieting, overtraining), many individuals may have impaired conversion of T4 to T3.

We all know thyroid hormones play an important role in metabolic rate and an increase in thyroid hormone levels can produce significant increases in energy expenditure.

This is, after all, why bodybuilders and fitness athletes will use synthetic T3 as they know it can help dramatically increase the rate at which they reduce fat mass.

In fact, excess thyroid levels have been known to increase metabolic rate by 25-50% in some cases and a person that is hypothyroid can have a decrease in metabolic rate by as much as 40% below normal (20).

Now, we're not saying that we can increase thyroid hormone levels to the same degree that you'd get from taking exogenous thyroid hormone, but imagine if you could get even a fraction of that – the results would speak for themselves!

An extract from the plant Bauhinia purpurea has been shown in healthy adult animal models to increase T4 by approximately 37% compared to controls, while increasing T3 by an amazing 83%! (21)

If this wasn't exciting enough, another study found that Bauhinia purpurea was able to completely restore the decrease in thyroid hormone levels seen when giving healthy adult animal models the drugs, dexamethasone (a potent glucocorticoid) and metformin (an anti-diabetic drug) (22).

Yet another reason that increasing thyroid hormone is so important is because it's known to sensitize or increase the lipolytic effects of adrenergic stimulation (i.e., through compounds such as the geranium and Cirsium oligophyllum extracts, along with caffeine) in fat cells (33).

Due to the results of the studies, the authors concluded that the plant is likely increasing the conversion of peripheral T4 to the more potent T3.

This is like adding a NOS injector to your ten speed!

Bacopa monnieri (Leaf)

This plant has also been shown in an animal model to naturally increase thyroid hormone production. In this case, the plant extract was shown to increase T4 levels by approximately 41% compared to controls (23).

In this case, however, since there was no increase in T3 seen, the authors concluded that the plant extract directly stimulates the release of T4 from the thyroid gland, as opposed to Bauhinia purpurea, which increased the conversion of T4 to T3.

By combining the two plant extracts, the goal is to create a situation where your body will release more T4, while at the same time more of this newly released T4 will be converted to the more metabolically active T3.

This is truly the "best of both worlds" scenario & the end result potentially being a substantial increase in energy expenditure and decreased fat.

Cirsium Oligophyllum (Whole Plant Extract)

Our use of this plant is based upon an animal study which had shown that compared to a control group, the extract was able to reduce the gain of bodyweight and fat mass and specifically seemed to target subcutaneous fat mass over that of visceral fat mass with a ratio favoring the reduction of subcutaneous fat mass over that of visceral of nearly 9 fold!(5)

Pharmacological studies revealed that the active constituent possesses beta adrenoceptor agonist activity (other beta adrenoceptor agonists include compounds like ephedrine and clenbuterol) and stimulates lipolysis in subcutaneous fat cells.

Yet another similarity that the Cirsium oligophyllum extract shares with beta adrenoceptor agonists is that it works synergistically with caffeine, producing a more powerful lipolytic effect that far exceeds the effect when used by itself (5).

In fact, the potency of caffeine & Cirsium Oligophyllum combined was nearly 10 times greater than Cirsium Oligophyllum by itself.

As a final note, Uncoupling Protein-1 expression was up-regulated 1.3 fold, relative to controls in those animals receiving Cirsium Oligophyllum topically; more on this later (5).

Caffeine

Caffeine is often noted for its ability to increase resting energy expenditure, while also increasing lipolysis and lipid oxidation (6-8)...

In addition, it is noted for its ability to increase feelings of energy, alertness, concentration and euphoric effects (9,10).

Everyone throws caffeine in their formula...but few know why...we have a specific purpose on why we included it...

...Aside from the benefits that caffeine alone imparts, it can also provide synergistic effects when combined with other ingredients in OxyELITE Pro™...

In particular, the caffeine we have included may increase the effectiveness of the other fat loss agents included in the formula, including our Geranium extract as well as Cirsium oligophyllum.

...In fact, in the study performed with Cirsium oligophyllum, they found exactly that!

Caffeine was shown to provide a substantial increase in the effectiveness of the extract at promoting lipolysis in subcutaneous fat cells (5)...

Is Your Fat Burner Targeting The Wrong Fat?

Notice that we said subcutaneous fat cells as this is where many companies fail to make a distinction when creating fat loss products...

Many compounds can produce a decrease in fat mass when it comes to visceral fat (i.e., the fat that surrounds your organs), but when it comes to improving how you look, subcutaneous fat is what you're concerned with as this is the fat that is just below your skin and smothers up your muscles...

How Much Subcutaneous Fat You Have Means The Difference Between Looking Shredded Or Looking Like You Own Stock In A Donut House.

As you can see in the picture above, subcutaneous fat is what covers up your abs. The crappy high-stim fat burners these days target visceral fat, not subcutaneous fat.

Targeting visceral fat is important for overall health - and the compounds in OxyELITE Pro™ can target visceral fat too - but as you can see, targeting visceral fat alone isn't going to do much for that layer of fat surrounding your muscles...

You need to get rid of excess subcutaneous fat to make a lean physique a reality.

Geranium [Stems] (extracted for 1,3-Dimethylamylamine)

Geranium has been used for centuries as a food additive and part of certain cultures regular diets. One constitute of geranium is this compound - a sympathomimetic, aliphatic amine with indirect (i.e., by increasing norepinephrine levels) and/or direct activity at alpha and beta-adrenoceptors (1-3).

This compound's influence upon the sympathetic nervous system (SAS) and norepinephrine levels is something very important to consider as the SAS and norepinephrine are considered to play important roles when it comes to influencing metabolic rate and especially the rate at which we burn calories while at rest (4).

What does this all of this mean? It means this compound can potentially help provide the stimulation needed for better workouts (i.e., a feeling of more energy and focus), while also directly stimulating the use of fat as fuel in your body.

The Final Frontier – The Incredible Fat Loss Pathway Science Had All But Given Up On

Consider this the icing on the cake...the 10th Ring for Phil Jackson...the next Billion Bill Gates makes...

Brown Adipose Tissue (BAT)

So, I'm sure we've all heard of this before, right?

It's often referred to as BAT, or simply as brown fat. It's very metabolically active and uses fat as fuel in order to produce heat. Pretty cool stuff, right?

Unfortunately, we were under the assumption we really only have significant amounts of brown fat when we're babies...

So, that's the end of the story, right? Well, very recently, the answer has become a solid, but surprising, no.

As it turns out, we fell into that trap often referred to as dogmatic thinking. If we're told something enough times and no one challenges it, we believe it...

Very recently, scientific studies have begun to call into question the notion adult humans lack BAT and that it has no potential to play any significant physiological role (24-29).

So, without any more procrastination, let's delve into the most recent findings:

* A recent study found that up to 96% of subjects evaluated have detectable levels of BAT! (24,25).
* It has been found that those that are overweight have lower BAT activity than those that are lean, something that isn't entirely a coincidence as having more BAT can potentially mean expending more calories and thus maintaining a lower weight (25).
* It has been estimated that more than half of all men and women likely have at least 10 grams of BAT in their body (26).
* BAT is so metabolically active that as little as 50 grams of BAT could potentially account for up to 20% of total daily energy expenditure of an adult human when maximally stimulated (25,26).
* In one subject that was shown to possess 63 grams of BAT, it was estimated that when fully activated, this amount of BAT could burn approximately 4.1 kilograms (around 9 lbs) of fat mass over a year (25,27).
* That's around 9 lbs of fat lost by doing nothing but sitting on your butt!

Imagine how much of a difference that can make on how you look...

For example, let's start with a hypothetical 190 pound man with 12% bodyfat...

If he had 63 grams of BAT like the subject mentioned above & we can maximally stimulate BAT, he would lower his bodyfat down to 7.6%... by doing nothing differently except activating his BAT fat!

The difference in 12% & 7.6% bodyfat is flat-out staggering – 12% and people may ask you if you workout a few times a week...

A true 7.6% & you'll have chicks beggin' & dudes hatin'...

Ok Jacob, How Do We Recruit BAT?

The problem however is recruiting BAT and activating what little we have in the first place...

While exposure to cold is one method, it isn't exactly feasible to expose yourself to cold every day of the week...

...And aside from that, it has been pointed out that various environmental changes for modern humans such as insulated buildings, clothing advances and heated transport systems have all reduced the need for thermogenesis via BAT and thus the amount of activated BAT has decreasedas well...

But all hope is not lost...

The other method is via sympathetic stimulation or in other words, by using direct and indirect-acting sympathomimetics (25,28).

Where OxyELITE Pro™ Goes From All-Time Great to First Ballot Hall of Fame

First, it's important to understand how BAT provides such benefits...

Now, normal white adipose tissue or WAT (i.e., the stuff around your organs and smothering your muscles) is generally there to accept extra energy from calories ingested and accepts them for storage as triglycerides (fat).

We need this to insulate us from the cold and protect our internal organs. BAT, on the other hand doesn't store extra energy as it instead dissipates this extra energy in the form of heat.

As you can see on the left, Brown Fat is much more "active" & thus can create much greater heat production (i.e burning fat for energy) than White Fat.
How does it do this? A major factor is a protein called uncoupling protein-1 (UCP-1).

Protein Uncoupling

This protein is able to uncouple oxidative phosphorylation, allowing the energy from foodstuffs that we consume to be released as heat (burned) instead of stored as fat (25,28,29).

Have you ever had one of those very lean friends that always complains about being, "hot" all of the time, even when it's the dead of winter?

These are the same friends that seem to eat nothing but junk food, yet still manage to stay lean all the time!

Well, BAT and UCP-1 activity may, in fact, be part of the reason!

Not The Same As DNP

It's important to note this type of Protein Uncoupling IS NOT the same as the dangerous, yet highly effective, uncoupling compounds such as DNP...

Unlike DNP (an exogenous substance), UCPs are produced naturally in mammals, including humans...

Although they may have other roles, one is that they work to uncouple oxidative phosphorylation, hypothetically providing the same benefits as exogenous uncouplers (e.g., weight and fat loss), although this uncoupling is much more limited and won't lead to hyperthermia and the various side effects that exogenous and foreign uncouplers like DNP can lead to...

Granted, it also won't likely lead to the same weight loss and fat loss results as exogenous uncouplers like DNP, but it may help with fat loss through the same mechanism.

So, plants or compounds that up-regulate the expression of UCPs, such as this plant, may help with fat loss in this way.

How OxyELITE Pro™ Attacks BAT

Quick factoid: Did you know that about 14% of the increase in metabolism from ephedrine was attributed to BAT? (25)

First, Geranium extract has sympathomimetic properties & this makes it a great candidate for increasing UCP-1 expression and recruiting or regaining BAT so that we may use it once again.

Secondly, Cirsium oligophyllum has beta adrenoceptor agonist activity and, as would be expected, has actually been shown to increase UCP-1 activity in BAT of an animal model (5).

Third, caffeine has been shown to increase norepinephrine by up to 75% in one study.

This increased norepinephrine again contributes to increasing UCP-1 activity in BAT, unfortunately, it also ends up activating alpha 2-adrenoceptors...

...And by doing this, it actually inhibits some of the potential lipolytic and thermogenic activity of norepinephrine by inhibiting adenylyl cyclase (i.e., the enzyme which allows for cyclic adenosine monophosphate or cAMP formation and what ultimately leads to lipolysis) activity (25,28).

This is where rauwolscine comes in to play as it is an alpha 2-adrenoceptor antagonist. It prevents this inhibition of adenylyl cyclase and thus can potentially lead to a further increase in cAMP, lipolysis and thermogenesis via UCP-1...

Again, this is where rauwolscine shows its superiority to yohimbine...

You see, the alpha 1-adrenoceptor is also activated by norepinephrine and it also contributes to increased UCP-1 activity and subsequent thermogenesis (28,29,31,32).

At least one partial mechanism for how the alpha 1-adrenoceptor exerts such an effect is by increasing the conversion of T4 to T3 within BAT, which in turn increases UCP-1 expression.

...So, although yohimbine has some beneficial effect upon fat loss, it's this blocking of activity at the alpha 1-adrenoceptor that becomes its downfall. Rauwolscine is 50 times less potent at antagonizing the alpha 1-adrenoceptor and thus makes a much better agent to use for fat loss.

Last, but certainly not least, we still have both of our plant extracts designed to increase the release of T4 (Bacopa monnieri) and increase the conversion of T4 to T3 (Bauhinia purpurea).

As we just mentioned, T3 plays a very important role in UCP-1 expression so if we can elevate levels further, it is beneficial for a number of reasons...

...Of course, the fact that T3 can up-regulate beta adrenoceptor expression while down-regulating alpha 2-adrenoceptor expression, all while inhibiting phosphodiesterase (i.e., an enzyme that breaks down cAMP) activity further adds to increase or potentiate the effectiveness of the other ingredients (33).


References:
1. Anonymous. New and nonofficial remedies: methylhexamine; forthane. J Am Med Assoc. 1950 Jul 29;143(13):1156
2. Swanson EE and Chen KK. Comparison of pressor action of aliphatic amines. J Pharmacol Exp Ther. 1946 88(1):10-13
3. Charlier R. Pharmacology of 2-amino-4-methylhexane. Private Trans. Arch Int Pharmacodyn Ther. 1950 Sep 1;83(4):573-584
4. Diepvens K, Westerterp KR, Westerterp-Plantenga MS. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R77-85
5. Mori S, Satou M, Kanazawa S, et al. Body fat mass reduction and up-regulation of uncoupling protein by novel lipolysis-promoting plant extract. Int J Biol Sci 2009;5(4):311-318
6. Bracco D, Ferrarra JM, Arnaud MJ, et al. Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women. Am J Physiol. 1995 Oct;269(4 Pt 1):E671-E678
7. Dullo AG, Geissler CA, Horton T, et al. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. Am J Clin Nutr. 1989 Jan;49(1):44-50
8. Acheson KJ, Gremaud G, Meirim I, et al. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? Am J Clin Nutr. 2004 Jan;79(1):40-46
9. Kaplan GB, Greenblatt DJ, Ehrenberg BL, et al. Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans. J Clin Pharmacol. 1997 Aug;37(8):693-703
10. Smith A. Effects of caffeine on human behavior. Food Chem Toxicol. 2002 Sep;40(9):1243-1255
11. Berlan M, Galitzky J, Riviere D, et al. Plasma catecholamine levels and lipid mobilization induced by yohimbine in obese and non-obese women. Int J Obes. 1991 May;15(5):305-315
12. Galitzky J, Taouis M, Berlan M, et al. Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers. Eur J Clin Invest. 1988 Dec;18(6):587-594
13. Flechtner-Mors M, Jenkinson CP, Alt A, et al. In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects. J Pharmacol Exp Ther. 2002 Apr;301(1):229-233
14. Sax L. Yohimbine does not affect fat distribution in men. Int J Obes. 1991 Sep;15(9):561-565
15. Kucio C, Jonderko K, Piskorska D. Does yohimbine act as a slimming drug? Isr J Med Sci. 1991 Oct;27(10):550-556
16. Berlin I, Stalla-Bourdillon A, Thuillier Y, et al. Lack of efficacy of yohimbine in the treatment of obesity. J Pharmacol. 1986 Jul-Sep;17(3):343-347
17. Zahorska-Markiewicz B, Kucio C, et al. Adrenergic control of lipolysis and metabolic responses in obesity. Horm Metab Res. 1986 Oct;18(10):693-697
18. Perry BD, U'Prichard DC. [3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors. Eur J Pharmacol. 1981 Dec 17;76(4):461-464
19. Berlan M, Le Verge R, Galitzky J, et al. Alpha 2-adrenoceptor antagonist potencies of two hydroxylated metabolites of yohimbine. Br J Pharmacol. 1993 Apr;108(4):927-932
20. Kronenberg HM, Melmed S, Polonsky KS, Larsen PR.: Williams Textbook of Endocrinology, 11th ed., Saunders Elsevier, Philadelpha, PA, 2008.
21. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol. 1999 Nov 1;67(2):233-239
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