ProSupps i-Load

What is I-LOAD™?

I-LOAD™, short for “Insulin Load”, was designed to help athletes increase the storage of
carbohydrates, amino acids, creatine and other nutrients within muscular tissue.

Main benefits of I-LOAD™ Include:

• Increase amino acid uptake in muscle tissue
• Increase insulin receptor sensitivity
• Increase glycogen storage in muscle tissue
• Increase protein synthesis and DNA replication
• Increase potassium uptake
• Increase blood flow
• Decrease breakdown of protein
• Enhance nutrient partitioning

How important is Insulin for building muscle?

Insulin is the most powerful anabolic hormone in your body that has the ability to increase
protein synthesis, inhibit protein breakdown and transports glucose, amino acids and creatine
into muscle tissue. Almost every amateur and professional bodybuilder is familiar with the
power of insulin due to the powerful glycogen pump it can produce along with hyper-loading of
nutrients post workout. In addition, insulin also has a huge nutrient-partitioning effect, driving
food (and stored food energy) into building muscle instead of building fat. The challenge with
using prescription insulin is that if you make one bad mistake it could cost you your life or put
you into a coma. Not good. So the key here is to manipulate this powerful hormone without
risking the dangerous side effects.

Why is insulin sensitivity important?

One of the key elements to managing the power of insulin (and maintaining health), is to
increase one’s insulin sensitivity and also reduce the chance of becoming insulin resistance.
A person who is “insulin resistant” has a hard time processing carbohydrates and their body
releases a ton of insulin to get glucose into the resistant cells. This “resistance” is not a good
thing, & overproduction of one’s own insulin can lead to type 2-diabetes which can cause kidney
failure, blindness, arterial disease and coronary heart disease. The key to an efficient, healthy
body is to increase insulin sensitivity where the body doesn’t have to release a ton of insulin to
get the glucose into the cell. Insulin sensitivity is partly genetic and varies with each individual
usually peaking highest in professionally trained athletes. Three of the best ways to increase
insulin sensitivity is through resistance training, cardiovascular training and manipulating one’s
diet.(1)(2) A moderate carbohydrate diet rich in Omega-3 fatty acids, fish oil and fiber can make
a dramatic impact upon one’s insulin sensitivity. On the flip side, the low-carbohydrate, high-
fat diets that have become popular lately can decrease insulin sensitivity. People should be very
careful of these types of diets and limit their use to a maximum of 3 weeks at a time especially if
muscle gain is one’s preferred goal.

How do I use I-LOAD™?

To feel the effects of a full-on glycogen pump, take (1-2) capsules with your pre-workout meal
or shake. Meal or shake must contain at least 40-50 grams of carbohydrates per capsule. For
increased amino acid & glucose uptake and speed recovery, take (1-2) capsules immediately
post-workout with at least 40-50 grams of carbohydrates per capsules. Advanced users may take
(1) additional capsule per day with a carbohydrate rich meal. Do not exceed 6 capsules per day
unless you are facilitating pre-contest carb loading.

How does I-LOAD™ work?

There are quite a few supplements that can help increase insulin receptor sensitivity and also
drive glucose from the blood and into the muscle cell. The Glut-4 receptor inside your cell is the
nutrient “gate keeper” that opens or closes depending upon the amount of insulin that is present
in the blood. I-LOAD™ was designed to open up the Glut-4 flood gates & pull glucose out of
the blood and into the muscle. This helps your body work more efficiently and keeps insulin
sensitivity at its maximum.

I-LOAD™ is not your simple ALA/chromium combination. Utilizing cutting edge science, I-LOAD™
uses the following powerful weapons to help keep insulin sensitivity at its maximum and store
nutrients like no other product currently on the market:

Banaba Leaf
Banaba (Lagerstroemia speciosa) is a plant native to India, Southeast Asia and the
Philippines and has several medicinal uses. In many cultures the banaba leaf is brewed
into a tea and used as a treatment for diabetes and as a weigh loss aid. Banaba Leaf
Extract provides a blood sugar lowering effect similar to that of insulin in that it induces
glucose transport from the blood into body cells. Recently, researchers have isolated an
active ingredient in the banaba leaf called corosolic acid which was originally thought to
be "the" blood sugar regulating substance in the leaf. Other researchers have found that
corosolic acid may not be the only active ingredient in banaba leaves. A study published
in the journal Planta Medica in 2001 compared a whole-leaf extract of banaba with
insulin in cell cultures. The researchers concluded that the whole herb has a glucose
lowering effect. Another study reported that banaba leaf extract contains at least three
active ingredients that effect blood sugar.

In animal studies, administration of banaba leaf extract resulted in a significant decrease
of blood glucose. The same studies suggest that corosolic acid may stimulate glucose
transport into tissue. In other animal studies, administration of banaba leaf extract
resulted in reduced weight gain, reduced triglyceride accumulation and reduced adipose
tissue, with no changes in diet.

Gymnema Sylvestre
Gymnema Sylvestre is another herb, whose traditional use in treating diabetes, has been
backed up by recent medical research. Originating from India, Gymnema Sylvestre
is known as gur-mar, or "sugar destroyer." When gymnema leaf is placed directly on
the tongue, it eliminates the sensation of sweetness, even if sugar is put in the mouth
immediately following. When taken internally, it helps to control blood-sugar levels in
diabetes. The leaves of Gymnema sylvestre perform two significant functions relative to
diabetes. First, they suppress blood glucose, especially after eating. Secondly, they are
insulinotropic and promote insulin secretion. By this two-pronged approach, Gymnema
sylvestre proves a valuable aid in diabetes control.

Scientists think its active ingredients (gymnemic acids) protect the cells of the pancreas
from free radical damage, so allowing them to regenerate and produce insulin more
effectively (Nutrition 2004; 20(3): 280-285). Studies have shown that gymnema can

reduce glucose absorption from the intestine, so helping to regulate blood sugar levels.
A recent Harvard study indicates the Gymnema lowers blood sugar levels in Type I
and Type II diabetics. At King's College in London, study stated that Gymnema acts by
increasing cell permatibility, therefore reducing insulin resistance.

Momordica 10:1 Extract
Bitter melon is the common name for Momordica charantia, also known as African
cucumber, balsam pear and bitter gourd. The plant is aptly named, as all parts of the
plant, including the fruit, taste bitter. Sold often in Asian groceries as a vegetable, bitter
melon is employed as a folk remedy primarily for regulating blood sugar in cases of
diabetes, as well as for colitis and dysentery, intestinal worms, jaundice and fevers. The
phytochemicals present in bitter melon suggest that there are multiple uses for this herb.
Among the constituents in bitter melon, charantin is identified as an important agent for
blood-sugar regulation. Charantin demonstrates hypoglycaemic (blood sugar lowering)
or other actions of potential benefit in diabetes. The Momordica fruit contain insulin-like
peptides, including one known as polypeptide P, and alkaloids. It is likely that several
substances in bitter melon contribute to its blood sugar-modifying effects. In human
studies, bitter melon demonstrates significant blood-sugar control after food intake and
overall blood sugar-lowering effects.

In a study published in the journal Chemistry & Biology- March 2008, a research team,
headed by Dr. Mon-Jia Tan of the Chinese Academy of Sciences in Shanghai, concluded
that bitter melon has potent anti-diabetes effects. In their study, Tan and colleagues
isolated and described several compounds from bitter melon known as cucurbitane
triterpenoids, and tested their effects on glucose (sugar) and fat metabolism in cells and
in mice. When tested in muscle and fat cells, the researchers found, the compounds
stimulated the glucose receptor GLUT4 to move from the cell interior to the cell surface,
thus promoting more effective glucose metabolism. Several of the tested compounds had
effects comparable to those of insulin. Tests in mice of two of the compounds found that
they promoted both glucose tolerance and fat burning, and one was particularly effective
in promoting glucose tolerance in animals consuming high fat diets.

The researchers note that there may be as many as 70 active compounds in bitter
melon. "The present study provides an important basis for further analysis of structure-
activity relationship to develop optimized leads from (bitter melon) for the treatment of
insulin resistance and obesity," they conclude.

Momordica has been found to be just as effective as glibenclamide in reducing blood
sugar levels (J Ethnopharmacol 2003; 88(1): 107-111). In fact, a large study at Harvard
University Medical School concluded that mormodica is one of the best natural remedies
for diabetes (Diabetes Care 2003; 26(4): 1277-1294). It appears that mormodica contains
compounds similar in structure to insulin, which have the same effects in regulating
blood sugar levels. There is evidence that mormodica can prevent the release of excess
glucose into the bloodstream from the liver (Am J Health Syst Pharm 2003; 60(4): 356-
359).

Chromium Polynicotinate
Chromium helps insulin transport sugar to the cells. Chromium works to make insulin
more effective by "bridging" insulin to cell membranes, thus increasing the number
of active insulin receptors, resulting in increased insulin sensitivity. The trace mineral
chromium is found in skin, fat, muscle, brain and the adrenal glands. There is about 6 mg
in each of us and it is important! Chromium absorption through the small intestine is very
poor; so normally, a lot of it gets excreted in urine. People with diabetes excrete even
more chromium than healthy people; and the loss of this vital nutrient makes it harder for
their bodies to respond to insulin. Studies show that chromium supplements can help both
Type I and Type II diabetics control their blood sugar.

There are various forms of chromium suitable for human ingestion. The Polynicotinate
form of chromium called "Chromium polynicotinate" is the most absorbable. Chromium
polynicotinate is a unique molecule that binds chromium with niacin, a compound found
in breast milk, which helps the body better absorb and process minerals.

In June of 2002, one form of chromium was affirmed by the FDA as "Generally
Recognized as Safe" (GRAS) for use in food products, one of only a handful of
ingredients to have secured this status at clinically effective doses for use in foods
marketed for weight loss and glucose control.

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