Testosterone Maximizer Stack - Fix Low Testosterone Problems or Add to PCTApplied Nutriceuticals Free Test (100 capsules)
E-Pharm TestForce (90 grams)
Applied Nutriceuticals Free Test - Turbo-Charges Free Testosterone Output!
What's better than a Pro-Hormone? FREE TEST™!!!
The prohormone ban has come and gone. Yeah, there are a few still out there…the ones nobody wants because they don’t work. There might be a few dirty compounds floating around the internet from some shady companies too – and they’re not even remotely worth the risk. So what’s a guy who looking for REAL, HARDCORE gains supposed to do NOW?
Enter the era of the hANh™ (Hybrid Anabolic / Near Hormonal); which is defined as a product that engages a synchronization of natural and exogenous factors to produce a pronounced anabolic and hormonal response. The distinct advantage of a hANh is that the user is able to obtain maximal physiological benefits comparable to that of fully hormonal products while minimizing potential side effects and disruption of endogenous factors post-usage. Applied Nutriceuticals® pioneered this product category with HGHup♂™ and now takes it a step further with FREE TEST™.
FREE TEST cranks your testosterone levels like no other product because it hits the problem from two separate directions: On one hand it focuses on decreasing the body’s mechanisms that lower endogenous (natural) testosterone production – the most prominent one being cortisol. On the other hand it increases the testicular output of testosterone. The net result? An exponential improvement in the Anabolic / Catabolic Ratio (the proportion of Testosterone vs. Cortisol) – and even more importantly - it targets increases in the amount of FREE (direct) TESTOSTERONE, which is unbound and readily available to exert it’s anabolic effects on your body! And THAT, my friends, is what directly leads to huge increases in massive, rock-hard muscle. (Not to mention your sex life will go on turbo as well…you can thank us for that later!)
Below are actual test results from 6 test subjects after taking FREE TEST:
Here’s the best part: FREE TEST IS NOT A PROHORMONE nor does it convert to any hormone - so it is completely safe. So, if you were bummed when the prohormone ban went down…don’t be. We’ve got you covered.
Here’s a little of the “techie” stuff about how it works:
- *FREE TEST positively alters 7 homeostatic mechanisms of action that effect free and total testosterone output:
- *Contains a natural suicide inhibitor of aromatase, and will improve the Testosterone : Estrogen (T:E) profile while concurrently increasing testosterone levels
- *Increases NO/cGMP levels, which leads to increases in lutenizing hormone (LH) and greater endogenous testosterone production.
- *Increases testicular Acetyl L-Carnitine (ALCAR) levels. High testicular ALCAR levels are conducive to heightened spermatogenesis.
- *Lowers levels of cytokines IL-6, IL-1, and TNF-alpha- cytokines, which inhibit endogenous testosterone production by reducing levels of LH.
- *Lowers cortisol levels and heightens Testosterone : Cortisol (T:C) ratio via competitive inhibition processes.
- *Increases cAMP levels, which also increase LH levels.
- *Influences/Increases androgen receptor (AR) binding via altering receptor electro-negativity.
After 8 weeks of usage of FREE TEST, test subjects were observed to have increased levels of free testosterone ranging from 50-200% over baseline. Impressive results for any product – especially one with no negative side effects!
Furthermore, the subjective feedback from the FREE TEST beta testers was nothing short of amazing. Within the first week users experienced feeling more motivated and assertive with shirt-splitting pumps, big-time strength increases, and revved up libido…all within the first week!
EFFECTS RELATED TO PHYSIQUE AND LIFE ENHANCEMENT:
- *Greater lean muscle mass
- *Lowered body fat
- *Better/Faster recovery from training
- *Increased muscular strength
- *Heightened libido and sexual drive
The basics of how FREE TEST works:
The main mechanism of action in FREE TEST has to do with the anabolic/catabolic ratio in skeletal muscle, catabolic principles, and how they relate to homeostasis. During an anabolic steroid or prohormone cycle, testosterone levels rise, creating an anabolic state; as the testosterone to cortisol ratio (T:C) will become very positive. (See Figure 2: Notice the separation between the blue and pink lines at the beginning of the cycle). This allows for increased protein synthesis, and increases in lean body mass. However, due to homeostatic mechanisms in the body, cortisol levels begin to rise along with the increase in testosterone after the first 1-2 weeks (Note how the blue and pink lines come closer and closer together). The body seeks to gain balance (homeostasis) over the increased anabolism via modulating cortisol levels. The body recognizes that it cannot be in a state in which it requires such large amounts of nutrients for protein synthesis and lean tissue accretion for very long (a very high positive nitrogen balance), so it essentially tries to put the brakes on, via increasing cortisol levels to meet heightened testosterone levels (53).
Figure 2: TESTOSTERONE AND CORTISOL LEVELS DURING A PROHORMONE OR ANABOLIC / ANDROGENIC STEROID CYCLE:
This phenomenon occurs during every cycle and it is why, after week 6 of a cycle, gains slow dramatically, or stop altogether due to the homeostatic rise in cortisol. When this occurs, the user has one of two options: (1) Cessation of the cycle, followed by post-cycle therapy ((PCT) - note the pink line above the blue in wks. 10-12, indicative of a catabolic state), or: (2) Increase the dosage, and take the level of testosterone up even higher (not recommended for safety reasons).
Neither option is very good for keeping gains. The mechanism of action of Free Test seeks to circumvent this via manipulating the T:C ratio via non-androgen receptor mediated means. One key ingredient, 3, 7 keto DHEA plays a key role in accomplishing this. Here’s how it works: 7-Keto derivatives competitively interact with the 11beta-HSD1 enzyme, which is the enzyme that allows the transfer of inactive glucocorticoids to active ones. This is important as it therefore helps keep cortisol levels lower than normal by slowing (but not stopping) the conversion of inactive cortisol to active cortisol - allowing for mitigated levels of this catabolic hormone. (46-48).
Non-androgen receptor (AR) mediated methods of increasing testosterone are extremely crucial to the inner workings of Free Test. Another mechanism of action is that it exerts its effects through deceased estrogen levels, increased testicular function, and increased levels of luteinizing hormone (LH) (53). Since these controls are non-AR mediated (at least not directly), the rise in testosterone is more gradual and not as traumatic, consequently the body will not try to maintain homeostasis as stringently as with the dramatic increases seen with an AR-mediated cycle (see Figure 3 below).
Figure 3: THEORETICAL TESTOSTERONE AND CORTISOL LEVELS DURING A FREE TEST™ CYCLE:
These more gradual increases in testosterone levels allow for cortisol levels to remain relatively low during the cycle. Additional factors that directly suppress cortisol further improve the anabolic ratio (T:C), with anabolism far outweighing catabolism throughout the cycle, with minimal disruption of hormone levels post-cycle (53).
Figure 4: OVERVIEW OF THE HYPOTHALAMIC PITUITARY TESTICULAR AXIS:
Figure 5: POTENCY OF AROMATASE INHIBITORS, INCLUDING 3-DESOXY 7-KETO DHEA (KI VALUES):
FREE TEST™ MAIN MECHANISMS OF ACTION:
Regulating Estrogen and Increasing Testosterone via Suicide Aromatase Inhibition: The Role of 3, 7-Keto DHEA:
3, 7-Keto DHEA is a naturally-occurring metabolite of dehydroepiandosterone (DHEA), and is a potent aromatase inhibitor with some very unique qualities. Aromatase is an enzyme that transforms testosterone into estrogen, and the more active aromatase is, the more estrogen will ultimately be present. Therefore, aromatase inhibitors significantly decrease the level of estrogen in the body. This is important as increased estrogen in men can signal the hypothalamic pituitary testicular axis (HPTA) to shut down the release of gonadotropin-releasing hormone (GnRH). GnRH signals the production of luteinizing hormone (LH), which signals the production of testosterone. Therefore, increased estrogen levels can lower endogenous testosterone production (21,29,31).
3, 7-Keto DHEA has demonstrated strong ability to lower estrogen, thus mitigating this effect. It has a high binding affinity (Ki value = 0.22 mM) to the aromatase enzyme, and binds in an irreversible manner, making it a suicide inhibitor of aromatase. Ki Values measure how efficiently a compound binds to its associated receptor. The lower the Ki value; the higher the binding affinity. This inhibition allows for the production of less estradiol (E2) and estrone (E1) and allows the user of the compound to maintain a higher level of testosterone; hence improving the Testosterone: Estrogen (T:E) ratio. The mechanism through which aromatase inhibitors raise testosterone is fairly simple; the HPTA senses low levels of estrogen, and because the body seeks to maintain homeostasis (it likes to maintain at least some estrogen, even in men), there is a concurrent increase in the amount of testosterone that is being produced, as a way to compensate for the low estrogen levels. The increased testosterone levels normally will result in increased estrogen since there is no estrogen being produced. Essentially, the brain is tricked into trying to produce more estrogen, so it releases more luteinizing hormone releasing hormone (LHRH) and subsequently more LH, leading to even higher testosterone levels (20,21-23).
All aromatase inhibitors share this characteristic of positively altering the T:E ratio, and all will raise serum testosterone levels in men, which has been referenced in numerous studies. 3,7-Keto DHEA is comparable in potency to several other commonly available aromatase inhibitors. As explained above, a lower Ki value means higher potency, making it more potent than both Formestane and Exemestane, and very similar to androstentrione (ATD) (31,55). (See Figure 5)
3,7-Keto DHEA is unique from other commonly used aromatase inhibitors in sports supplements in that it is a natural metabolite of 7-Keto DHEA and it cannot directly bind to the androgen receptor. 3,7-Keto DHEA (like 7-Keto DHEA) also cannot convert to testosterone, estrogen, or progesterone via any type of enzymatic reaction, so by strict definition it cannot in any way be considered a prohormone. This clearly differentiates it from other recently banned products that allow for the direct conversion to a controlled substance in the body (in either in trace amounts or full-scale conversion). This can not occur with 3,7-Keto DHEA, as it is formed naturally in humans from 7-Keto DHEA and can be readily found in humans in the amount of 5-7 ug/day (23-24).
Increasing luteinizing hormone via elevating nitric oxide and cyclic Guanosine Monophosphate (cGMP): The role of Acetyl-L-Carnitine, Resveratrol, and their interaction with the male reproductive system and StAR:
FREE TEST™ strongly influences testosterone production through the nitric oxide pathway and cGMP by increasing luteinizing hormone levels. Luteinizing Hormone (via receptors found on the surface of Leydig cells) is important as it controls the production and secretion of testosterone (1-4).
The inclusion of Acetyl L-Carnitine (ALCAR) (a derivative of L-Carnitine which is an amino acid that is crucial for fatty acid metabolism and male reproductive function) allows for this manipulation of cGMP, as does Resveratrol. cGMP is classified as a second messenger, meaning that it exerts its effects by acting in a manner secondary and in response to a first messenger signaling molecule. When a first messenger signaling molecule binds to a cell surface, another secondary pathway is activated that increases cGMP production (1,15,19,27).
Increasing cGMP is extremely important to the action of FREE TEST, in that increased cGMP levels equate to increased levels of luteinizing hormone (LH). LH has a stimulatory action on endogenous testosterone production; so when cGMP levels increase, so do LH levels, and when LH levels increase, so does endogenous testosterone production. This effect has been well documented in recent research on PDE5 inhibitors (compounds that increase cGMP levels such as slidenafil (Viagra®). Researchers found that high cyclic GMP levels ultimately equate to higher testosterone levels.
ALCAR has also been shown to be an acetate donor to coenzyme A, allowing it to aid in the synthesis and function of acetylcholine, both peripherally and centrally. 7-Keto derivatives of DHEA (like 3,7-Keto DHEA) antagonize GABA-A receptors and functionally increase cholinergic expression. Through this mechanism of action, ALCAR and 3,7-Keto DHEA can increase cGMP levels, through increasing the amount of available acetylcholine- as mentioned above, more cGMP, more LH, more testosterone. (18,20,32).
ALCAR levels are very important for testicular function, in that low testicular ALCAR and L-Carnitine levels are strongly associated with testicular dysfunction and infertility. (28,30,33)
ALCAR has also been shown to have a significant effect on increasing Leptin levels, and has also been shown to be a potent factor in the male reproductive system. Leptin releases LHRH (luteinizing releasing hormone) by activating nitric oxide synthase (NOS), an enzyme that speeds the formation of nitric oxide (NO) from the amino acid L-Arginine. LHRH controls the release of luteinzing hormone (LH), and greater amounts of LHRH release equal greater amounts of luteinizing hormone (LH) release, which can allow for higher amounts of endogenous testosterone. Therefore, by increasing leptin levels and boosting LHRH release, ALCAR can have some additional positive effects on endogenous testosterone production (1-4,18).
L-Carnitine, ALCAR, and several derivations thereof have been shown to elevate Nitric Oxide (NO) levels. NO is important in that it regulates vascular tone, central nervous system stimulation, induces the release of LHRH and regulates cGMP levels. ALCAR and 7-Keto derivatives of DHEA have also been shown to elevate acetylcholine levels, which allow for a concurrent increase in cGMP production. NO also activates the release of LHRH which reaches the pituitary and activates the release of gonadotropins via the activation of neural NO synthase (NOS) in the pituitary gland (1-4, 15, 33-34).
The fact that cGMP has a stimulatory action on steroidogenesis via increased LH production is an important one. In numerous pathway studies, increases in cGMP increased phosphorylation of the steroidogenic acute regulatory protein (StAR). Increased phosphorylation of StAR is important, in that (StAR) is a Leydig cell cholesterol transfer protein that provides the building blocks for testosterone synthesis. Increased phosphorylation allows for increased StAR activation, and increased StAR activation is necessary for the stimulation of steroidogenic enzymes involved in the transfer of cholesterol to testosterone. This increase in StAR, and the greater transfer of cholesterol to testosterone can result in greater endogenous testosterone synthesis (15,33-34).
By increasing the intermediary between these two processes, a resulting positive shift in anabolism can occur. Therefore, high cGMP levels also equate to high levels of luteinizing hormone (the hormone responsible for mediating endogenous spermatogenesis), and when cGMP levels are elevated it serves as an intermediate in the signaling cascade that ranges from LH binding to testosterone production (15,33-34).
These results suggest that cGMP contributes to the control of basal steroidogenesis (endogenous testosterone production) in Leydig cells through the protein kinase G (PKG, and enzyme responsible for the activation of second messengers) -dependent modification of the StAR protein and interaction with LH. LH controls the production and secretion of testosterone, and the subsequent binding of LH with its receptor allows signaling through the cyclic AMP pathway through GTP binding proteins. Signal transduction occurs through the protein kinase A pathway as its principal signal transduction mechanism, and this ultimately allows for the release of testosterone after 30-60 minutes of LH stimulation (15-17,33-34).
To summarize, FREE TEST™ contains several potent direct mechanisms of action that strongly influence the production of increased testosterone via the NO / cGMP pathway, through a cascade of regulatory proteins and second messengers.
Forskolin and Resveratrol: Increasing endogenous testosterone production via increasing Cyclic AMP (cAMP) levels:
Forskolin has been the subject of research in the supplement industry since the early 1980s. Scientific studies have discovered that along with increasing thyroid activity and thermogenesis, forskolin is also a potent anabolic. This occurs primarily through elevation of 3,5 cyclic adenosine monophosphate (cAMP) which is another second messenger that is important in hormone signaling (14,16).
cAMP elevation is a crucial piece of the puzzle in creating both an anabolic and thermogenic state, and forskolin is one of the best compounds available for triggering dramatic increases in cAMP levels. One study showed that forskolin was able to increase cAMP levels 4.82 times more than a placebo. Another study demonstrates that forskolin can raise cAMP levels in fat cells. This is important because it demonstrates the ability of the compound to enhance lipolysis; meaning that forskolin exerts powerful fat-burning effects as well as being a potent anabolic agent; plus forskolin can also enhance endurance capacity as well (5-10,14,16).
Another added bonus of forskolin and resveratrol are that they both increase cAMP independently of epinephrine, thus providing increased energy without the need to take any type of traditional stimulant. Increased cAMP also is a signal for steroidogenesis (testosterone production) in the Leydig cells of the testes by increasing levels of steroidogenic acute regulatory protein (StAR- as mentioned above) (14,16,36-38).
FIGURE 6: Forskolin-Induced Lean Body Mass Gains (Badmaev et al. 2001)
As mentioned earlier, StAR activation is necessary for the stimulation of the transfer of cholesterol to testosterone. By this process, and the fact that high cAMP levels also equate to high levels of luteinizing hormone, significant increases in endogenous testosterone production can occur along with a resulting increase in anabolism and protein synthesis (14-15).
Numerous other studies have shown parallels between increased cAMP levels and increased anabolism, and a ground-breaking 2005 study in The Journal of Obesity Research found that obese men taking 250 mg of 10% forskolin a day for 12 weeks (roughly the dosage included in the daily dosage of Free Test™) experienced an averaged 33% increase in free testosterone levels, averaged a 10 lbs. fat loss per person and increased lean mass an average of 8 lbs! A 2001 study by Badmaev (see Figure 6) also yielded similar results (6,8,54).
Quercetin is a citrus bioflavanoid that has been shown to boost the effects of resveratrol (this is the primary rationale for its inclusion in the formula) via prevention of precocious glucorindiation (deactivation of the compound) by the liver. Similarly, quercetin has also been shown to have some estrogen-antagonizing effects. Quercetin has also been shown to have some additional anti-oxidant effects, and has been shown to lower cortisol levels in several animal studies. Lastly, the combination of resveratrol and quercetin also has been shown in some cellular studies to actually destroy fat cells. (39,40,44)
Mitigating the factors that decrease testosterone, and how FREE TEST™ combats them via N-Acetyl-Cysteine and Selenium:
FREE TEST offers yet another benefit in the production and elevation of free testosterone, as it serves as a strong anti-oxidant in the reproductive system.
Cytokines are substances secreted by the immune system that carry signals between cells, and have effects on the function of many different bodily systems, including the function of endogenous testosterone modulation (25-26,35). Cytokines can be disruptive to the endocrine system, in that they can be involved in feedback inhibition during the production of testosterone, which can result in a downgrade of natural testosterone production. Under conditions such as systemic or testicular stress, the systemic and local (within the testis) amounts of pro-inflammatory cytokines (TNF, IL-1, and IL-6) will be increased significantly. Elevated amounts of cytokines can therefore be associated with decreased testicular function. Elevated levels of these cytokines will effect the endocrine system and alter the amount of hormones released by the system (mainly GnRH, LH and FSH), which regulate the spermatogenic process. Cytokines (mainly IL-6) can also significantly raise cortisol levels, which can also lead to a reduced anabolic stimulus (13,25,35).
In addition, Pro-inflammatory cytokines can suppress the cells of the testis, and lead to a decrease in spermatogenesis and thus to affect the function and/or viability of the testes in the production of testosterone (33-34).
Figure 7: ALTERATION OF HORMONAL PRODUCTION VIA CYTOKINES:
A recent study involving men taking a combination of N-Acetyl-Cysteine (or NAC, a precursor to glutathione), and selenium, (a trace mineral that has been shown to have direct effects on the biosynthesis pathways of testosterone), found that the combination of the two compounds has a mild synergistic effect on increasing testosterone levels in men. Selenium is rate-limiting in testosterone production in men, and if not enough selenium (selenium deficiency is very common) is available, testosterone will not be produced in optimal levels (25-26,49). The researchers also believe that the combination has an antioxidant effect in the testes via increasing glutathione levels. Glutathione is a tripeptide thiol found in all cells of the body, and is responsible for regulating protein synthesis and detoxifying cell structures. Selenium is needed for the detoxifying enzyme glutathione peroxidase, and NAC significantly increases glutathione levels. Increases in glutathione and glutathione peroxidase seem to be negatively correlated with cytokine release; as levels of these anti-oxidants increase, cytokine levels decrease. This effect is readily apparent in the male reproductive system, as several studies have shown that NAC can reverse testicular damage cross-indicated with cytokine release and cytokine-related testicular suppression. This characteristic alone promotes conditions that are extremely favorable for optimal testosterone production (25.49).
FIGURE 8: INCREASED TESTOSTERONE LEVELS RELATED TO N-ACETYL CYSTEINE AND SELENIUM SUPPLEMENTATION: STUDY DATA:
Modulating glucocorticoid and cortisol: Another way FREE TEST™ preserves the anabolic environment:
Glucocorticoids are a class of hormones that bind to the glucocorticoid receptor, and serve to prevent inflammation in the body. Cortisol is the most prevalent of the glucocorticoid hormones. It is a corticosteroid produced in the adrenal cortex of the kidney, and is used by the body as a response to stress. The release of cortisol is controlled by adreno-corticotropin-releasing hormone (45-47, 53).
Cortisol does have some benefits; for example cortisol is necessary for obtaining an optimal response to stimulant products, along with many body processes. The main function of cortisol is to increase blood sugar, but it can also counteract several different anabolic hormones in the body, including insulin and testosterone, thus acting in a catabolic function by tearing down muscle tissue when it is present in excessive amounts (53).
A negative Testosterone:Cortisol (T:C) ratio essentially starves muscle cells of nutrients by reducing muscle glycogen and potassium and weakening the immune system which can cause a general loss of muscle mass. A positive T:C ratio is necessary to produce an anabolic environment in the human body (53).
7-Keto DHEA, DHEA, and most derivations of this molecule have been found in many research studies to have the ability to significantly reduce glucocorticoid levels by altering cytokine levels, as discussed earlier in this article. They also modulate the negative immune effects of glucocorticoids on skeletal muscle that occur via competition for the 11beta-hydroxysteroid dehydrogenase 1 enzyme. The finding from initial pilot studies strongly suggest that 3, 7-Keto DHEA will produce potent immuno-modulating and cortisol-lowering effects similar to or possibly even greater than those associated with 7-Keto DHEA (22-23,45-47).
One of the aforementioned means through which 7-Keto DHEA and its metabolites serve this function is via acting on 11beta hydroxysteroid dehydrogenase 1 (11beta-HSD1), which is an enzyme that converts inactive glucorticoids to active substrate. 7-Keto DHEA and its analogs have been shown to compete with inactive glucocorticoids for the 11beta-HSD1 enzyme, thus reducing the conversion of inactive glucocorticoids to their active, muscle-catabolic form via receptor site antagonism. A good example would be a reduction in the conversion of cortisone to cortisol, which is a process dependant on the 11beta-HSD1 enzyme. 7-Keto DHEA has been shown to reduce this conversion; thereby lowering cortisol levels (45-47).
FREE TEST™ creates a superior binding environment for existing androgens: The role of Zinc and Magnesium in promoting a better binding environment for Free Testosterone:
Magnesium has been shown in more recent studies to inhibit the binding of steroid hormone binding globulin (SHBG) and free testosterone. SHBG binds free testosterone and allows it to be excreted from the body without binding the androgen receptor. Magnesium keeps this from happening by altering the binding affinity of testosterone to SHBG, and thereby allowing for increased amounts of free testosterone to remain active in the bloodstream (41-43).
Other human research has shown that supplemental magnesium, when taken along with other ingredients like DHEA and Zinc, can significantly increase free testosterone. Low magnesium levels have been found to be correlated with high cortisol levels, and this can lead to a negative skewing of the T:C ratio (20,41-43) .
Zinc is involved in over 200 enzymatic reactions, allowing for the action of several different hormones: GH, testosterone, and insulin all require zinc for synthesis (42-43,53).
The inclusion of these elements in FREE TEST allows for greater numbers of androgen receptors and a better binding environment for testosterone in skeletal muscle, hence creating a better target for circulating free testosterone and allowing for greater binding of testosterone to the additional receptors. All of these factors contribute to the multiple, synergistic mechanisms that lead to the dramatically increased protein synthesis, better recovery, and increased muscle mass users experience while taking FREE TEST.
Administration, Timing, and Dosing:
Under normal conditions, diurnal cortisol levels tend to be highest shortly after waking, and these levels tend to decline during the day, reaching their lowest point in the evening. Although cortisol levels tend to decline during the day, stressful events punctuate spikes into said decline (see Figure 9). Similarly, diurnal testosterone levels tend be highest in the early morning, and tend to wane as the day goes on, also spiking in a periodic fashion. Taking this into account, the timing of the Free Test™ dosage is crucial in contributing to the effectiveness of the product (53).
Dosing the product within 1-2 hours of waking will allow the product to be most effective, in regards to both diurnal hormone regulation, and also the relative half-lives of the compounds included in FREE TEST™. This will allow for a reduction in heightened cortisol levels associated with diurnal fluctuations, and will allow for a continued time period of increased testosterone levels, for up to 12-18 hours after the AM dosage (See Figure 9).
Figure 9: THEORETICAL DIURNAL CORTISOL LEVELS WITH AND WITHOUT FREE TEST™:
A second dose of the product most likely will not be required later in the day due to the inclusion of 3, 7-Keto DHEA, as suicide aromatase inhibitors normally only require dosing every 18-24 hours (21-22).
A dosage of 4-6 Capsules per day of Free Test™ is recommended, with food, within 1-2 hours of waking, depending on body weight.
Research involving blood testing of free and serum testosterone levels indicates heightened levels of testosterone within 1-2 weeks of the first dosage, with increases occurring up to weeks 3-4, and possibly longer (55).
FREE TEST can be run for much longer periods of time than conventional prohormones due to its effects on endogenous (naturally produced) testosterone, and the fact that it does not directly antagonize the androgen receptor. Instead, the product minimizes the homeostatic mechanisms in your own body that lower testosterone levels, and increases testosterone via secondary mechanisms of anabolism (manipulation of T:E and T:C). This allows the user to be able to run the compound for longer periods of time, up to 4-5 months while remaining safe and effective.
Stacks and Tips to Maximize the Product:
Stack product with HGH-Up♂- While each is extremely potent and effect on their own, there are distinct synergies with taking these product simultaneously. Their combined effects with rival that of even the most powerful prohormones without any of the risk associated with them.
Take Bio-Mend Anti-Oxidant formula
- *High ORAC Value
- *Protects cellular membrane
- *Protects transcriptional factors (mRNA and DNA)
In general, maintain a healthy diet and lifestyle:
- *Drink Plenty of water; at least 64 oz. per day
- *Ingest at least 1 gram of protein per lb. of body weight daily
- *Sleep at least 7 hours per night
- *Eat lots of fruits and vegetables
- *Eat lots of complex carbs
- *Eat 5-6 smaller protein and carb-rich meals throughout the day
- *Increase calories to at least 500 Kcal/day over your normal intake
- *BCAAs and Creatine will be helpful
- *Avoid alcohol and tobacco
In conclusion, FREE TEST™ is the most effective DSHEA compliant Testosterone enhancement product yet to be offered in the history of sports nutrition.
Q: When is the best time to take FREE TEST?
A: FREE TEST works best when taken early in the day, with food. This is the best way to simultaneously suppress cortisol and boost testosterone and maintain optimal levels throughout the day.
Q: How is FREE TEST different from other test boosters?
A: FREE TEST increases muscle anabolism via 7 mechanisms of action that work the problem two main directions: On one hand it stimulates endogenous testosterone production and androgen receptor quantity; on the other hand it suppresses muscle-destroying cortisol. The end results are dramatic.
Q: What are the main benefits of taking FREE TEST?
- *Increased lean muscle mass
- *Lowered body fat
- *Better/Faster recovery from training
- *Increased muscular strength
- *Heightened libido and sexual drive
Q: Do I need a PCT (Post-Cycle Therapy) product after I cease taking FREE TEST?
A: No! In fact, FREE TEST is a strong aromatase inhibitor that triggers your natural production of testosterone; so it can actually be used AS a PCT.
Q: How long should I cycle on / off FREE TEST?
A: Typical cycles are 8-12 weeks, with at least 4 weeks off in-between.
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E-Pharm TestForce2 - Dual Action Natural Testosterone Elevator!
TestForce2 contains the most soluble form of d-aspartic acid combined with another remarkable amino acid known as sarcosine. This combination provides results clearly superior to other d-aspartic acid product formulations.
In case you aren’t aware, d-aspartic acid is the hottest supplement ingredient on the market right now. It has more scientific literature supporting its ability to act as a natural regulator of anabolic hormone (i.e. testosterone, growth hormone) release in the body than any supplement ingredient EVER.
E-Pharm was the company to bring you the premium form of d-aspartic acid – d-aspartate calcium chelate. This form is more than 75 times as water soluble as regular d-aspartic acid and soluble over a wide pH range. This ensures the most rapid and complete absorption possible. And now E-Pharm has taken the lead in d-aspartic acid technology again with the patent pending addition of the amino acid sarcosine.
Please allow me to explain why the inclusion of sarcosine is so vital to getting the most out of d-aspartic acid.
Why Sarcosine?Let me start with some background. When d-aspartic acid (DAA) is ingested it is absorbed into the body and taken up preferentially by endocrine tissues such as the hypothalamus, pituitary, and testicles. There it stimulates the activity of what are known as NMDA receptors. NMDA receptors are located on neurons and they regulate neuronal activity. DAA binds to a specific docking site (receptor) located on the NMDA receptor known as NMDA binding site.
In the hypothalamus the stimulation of NMDA receptors leads to the production of gonadotropin releasing hormone (GnRH). GnRH then stimulates the pituitary gland to release luteinizing hormone (LH) and follicle stimulating hormone (FSH). LH and FSH then in turn travel to the testicles to initiate the process of steroidogenesis, which leads eventually to the release of testosterone into the blood stream. Stimulation of NMDA receptors in the hypothalamus also leads to the release of growth hormone releasing hormone (GHRH) which in turn promotes the release of growth hormone from the pituitary gland.
So the key here is the NMDA receptor. The more you activate this receptor in the hypothalamus the greater the release of GnRH and GHRH, and ultimately testosterone and growth hormone.
The NMDA receptor is somewhat unique in that it requires activation by two ligands (a ligand is like a “key” to a receptor). In the hypothalamus the main ligand for the NMDA receptor is d-aspartic acid. The secondary ligand (or co-activator) is the amino acid glycine. Both DAA and glycine have specific binding sites on the NMDA receptor. These sites are known as the NMDA binding site and the glycine binding site respectively. Think of it this way - just like how firing a nuclear missile requires two soldiers to turn two separate keys, so the NMDA receptor requires binding by two ligands to initiate its influence on the firing of a neuronal signal.
So to review, administration of DAA leads to it’s uptake into the hypothalamus and binding to the NMDA receptors there. And to activate the NMDA receptor you also require adequate levels of ligands that bind to the glycine site of the NMDA receptor. Now common sense would lead one to assume that by ingesting supplemental amounts of glycine would ensure that glycine site co-activation is ensured. However the scientific literature has shown that this method has limited efficacy.
The reason that glycine administration is not very effective at stimulating NMDA activity is not completely straight forward, but one reason is because it is efficiently removed from the synapses by the reuptake regulator Glycine Transporter 1 (GT1).
Interestingly, much of the science published on the subject of stimulation of NMDA receptor activity revolves around the theory that NMDA receptor hypo-activity is a causative factor in schizophrenia. For years scientists have been investigating ways to stimulate NMDA activity as a means for treating schizophrenic patients. One of the most effective strategies has been through targeting the GT1 protein. And one of the most efficient means to do this is actually through supplementation with sarcosine.
Of course we aren’t concerned about treating schizophrenia here, what we are concerned with is maximally stimulating natural production of testosterone (or growth hormone). But the mechanism in question is exactly the same for both purposes. By blocking the re-uptake of glycine you increase the concentration of glycine in neuronal synapses, and therefore increase the influence of NMDA upon nerve transmission. In essence this is the exact way some anti-depressants (such as SSRIs) work, except the goal there is to increase binding and activating of serotonin or dopamine receptors, not NMDA receptors.
Blocking glycine reuptake is not the only mechanism through which sarcosine stimulates DAA activity. Sarcosine actually can itself bind to the glycine binding site of NMDA receptors. In fact, it binds with a higher affinity than even glycine. So basically it replaces glycine as well as serves as its own reuptake inhibitor. It totally solves the glycine co-activation issue in one shot.
Knowing all these facts you can see why sarcosine produces a rather dramatic effect on NMDA neuronal transmission compared to glycine itself, or other endogenous ligands for the glycine receptor such as d-serine.
ConclusionTo summarize, for d-aspartic acid to work to its maximum potential it must be taken with an efficient stimulator of the glycine binding site on the NMDA receptor. The most efficient non-drug stimulator we know of is the natural amino acid sarcosine.
TestForce2 contains 3 grams of d-aspartic acid (as d-aspartate calcium chelate) and 3 grams of sarcosine per serving. It also is flavored with a light fruit punch flavor and slightly sweetened to provide a very pleasurable taste experience. It dissolves almost instantly.
So if you like d-aspartic acid you will love TestForce2. And if you were one of the few “non-responders” to d-aspartic acid then you will also love TestForce2 because you will no longer be a non-responder. You would be a fool to settle for any other d-aspartic acid supplement.